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KMID : 0370220100540040316
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Yakhak Hoeji
2010 Volume.54 No. 4 p.316 ~ p.321
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Preparation of Amorphous Adefovir dipivoxil using Reverse Phase Column Chromatography and Solid Dispersion Method
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Yoon Myeong-Sik
Oh Da-Won
Maeng Hyo-Chan
Hong Hye-Suk
Park Mi-Kyung
Lee Yong-Tack
Lee Si-Beum
Cho Il-Hwan
Moon Byoung-Seok
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Abstract
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Adefovir dipivoxil which was originally developed by Gilead Sciences has been used as treatments of HIV and HBV, especially a therapeutics for HBeAg positive and negative chronic patients. We developed highly efficient purification method using reverse phase column chromatography for mass production and a stable amorphous Adefovir dipivoxil using solid dispersion method. Reverse phase column chromatography led to highly pure product, more than 99.7% by HPLC and can be used for mass production compared with normal column chromatography. Solid dispersion method containing watersoluble polymer and Isomalt showed improved stability of amorphous Adefovir dipivoxil against heat and moisture.
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KEYWORD
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Adefovir dipivoxil, reverse phase, column chromatography, solid dispersion, amorphous, purification, mass production
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